difference between priority mail express and priority mail refers to the key distinctions between two shipping services offered by USPS. Priority Mail Express is USPS’s fastest service, guaranteeing overnight delivery to most U.S. destinations, including weekends and holidays. It also includes features such as tracking, delivery guarantees, and $100 in insurance. On the other hand, Priority Mail is slightly slower, typically delivering within 1 to 3 business days, and it does not guarantee overnight delivery. Priority Mail is often used for less time-sensitive shipments, while Priority Mail Express is ideal for urgent deliveries.